Last Updated: April 2026 | Reviewed by: Korea Medical Tourism Editorial Team
Profhilo vs Rejuran: Which Injectable Should You Choose in Korea?
Patients visiting Korean clinics consistently report that choosing between Profhilo and Rejuran is one of the most common dilemmas they face during consultations in Seoul. Both treatments have earned devoted followings among international visitors, and Korea remains one of the few countries where both injectables are administered with such a high degree of clinical expertise and frequency. In fact, Korea accounts for a significant share of global Rejuran procedures, partly because the treatment was pioneered and popularized in Korean dermatology clinics before spreading internationally, making Seoul one of the most experienced destinations on the planet for this specific injectable category.
While the two treatments share some surface-level similarities — both are injectable, minimally invasive, and focused on skin quality rather than volume — their mechanisms, ideal candidates, and visible outcomes differ in meaningful ways. Understanding the distinction between Profhilo vs Rejuran before you book your clinic appointment in Gangnam or Apgujeong can help you set realistic expectations, communicate clearly with your dermatologist, and ultimately achieve the results you are looking for from your medical trip to Korea.
Clinical Perspective: A board-certified dermatologist practicing in Gangnam notes: “Many international patients arrive thinking Profhilo and Rejuran are interchangeable, but they have fundamentally different biological mechanisms. Profhilo works through ultra-high-concentration hyaluronic acid to stimulate collagen and elastin, while Rejuran uses polynucleotides derived from salmon DNA to trigger cellular repair. I often recommend combining both over a treatment plan rather than choosing one, depending on the patient’s age, skin condition, and goals.”
Understanding What Each Treatment Does
How Profhilo Works
Profhilo is a patented bio-remodelling injectable developed in Italy and distributed globally, containing one of the highest concentrations of hyaluronic acid (HA) available in any injectable product — 64mg per 2ml syringe. Unlike traditional dermal fillers, Profhilo does not add volume or shape to specific facial features. Instead, it disperses through the skin tissue via a patented NAHYCO thermal process, stimulating the production of collagen types I, III, and IV as well as elastin. The result is a visible improvement in skin laxity, hydration, radiance, and overall texture. Most patients require two sessions spaced four weeks apart for an initial course, with maintenance sessions recommended every four to six months. According to research published through PubMed / National Center for Biotechnology Information, HA-based bio-remodellers show measurable improvements in dermal density and elasticity within weeks of treatment.
How Rejuran Works
Rejuran, also marketed as PDRN therapy or salmon DNA therapy, uses polynucleotide (PN) fragments derived from purified salmon sperm DNA. These PN molecules closely resemble human DNA and are able to bind to adenosine receptors in skin cells, accelerating wound healing, stimulating fibroblast activity, and reducing inflammation. The treatment was developed in Korea and approved by the Korean Ministry of Food and Drug Safety, and it remains one of the most clinically studied injectables in the Korean aesthetic market. Rejuran is particularly well-regarded for repairing damaged skin, minimizing fine lines, tightening pores, and improving skin tone irregularities. The standard protocol involves three to four sessions spaced two to four weeks apart, with annual maintenance recommended thereafter.
Key Differences: Profhilo vs Rejuran Side by Side
Target Concerns and Ideal Candidates
Profhilo tends to deliver the most dramatic results in patients aged 35 and above who are experiencing early signs of skin laxity, dullness, and dehydration. It is especially popular among patients who want a visible glow and lifting effect without committing to more invasive procedures. Rejuran, by contrast, excels at skin repair and is particularly well-suited for patients dealing with acne scarring, enlarged pores, sensitive or inflamed skin, and fine textural irregularities. Younger patients in their late 20s or early 30s frequently choose Rejuran for preventative skin health. Both treatments can also be administered to the neck, décolletage, and hands, though facial protocols remain the most common application at Seoul clinics.
Injection Technique and Comfort
Profhilo is administered using the BAP (Bio Aesthetic Points) technique, which involves only five injection points per side of the face, totalling ten injections per session. This makes the procedure relatively quick — typically 15 to 20 minutes — and minimizes discomfort. Rejuran requires multiple microinjections distributed across the treatment area, which can feel more uncomfortable and may result in slightly more post-treatment redness and micro-swelling. Both treatments are typically performed with topical anaesthetic cream applied 20 to 30 minutes beforehand, and most clinics in Gangnam include this preparation as standard.
Downtime and Recovery
Neither treatment requires significant downtime, which is part of their appeal for international patients on short trip itineraries. With Profhilo, patients may notice small raised bumps at injection sites for two to four hours, and mild redness for up to 24 hours. With Rejuran, post-treatment papules (small raised welts) are more visible and may last up to 12 to 24 hours. Light swelling and redness can persist for one to two days. Most clinics recommend avoiding intense exercise, saunas, alcohol, and direct sun exposure for 24 to 48 hours after either procedure. The American Academy of Dermatology advises that patients discuss full post-care protocols with their treating physician before any injectable procedure, particularly when travelling internationally.
Cost Comparison in Korea: Profhilo vs Rejuran
Profhilo Pricing in Seoul
In Seoul, a single Profhilo session typically costs between ₩300,000 and ₩500,000 KRW (approximately $220 to $370 USD) depending on the clinic’s reputation, location, and whether any combination treatments are included. Most clinics recommend purchasing a package of two sessions for the initial course, which may cost between ₩550,000 and ₩900,000 KRW (approximately $400 to $660 USD) for the complete first round. Clinics in premium Gangnam locations may price at the higher end of this range, while clinics in other Seoul districts may offer more competitive pricing.
Rejuran Pricing in Seoul
Rejuran is generally priced slightly lower per session than Profhilo. A single Rejuran Healer session in a Gangnam clinic typically ranges from ₩200,000 to ₩400,000 KRW (approximately $145 to $295 USD). Full initial course packages of three to four sessions may cost between ₩550,000 and ₩1,200,000 KRW (approximately $400 to $880 USD). Premium clinics may offer specialized Rejuran variants such as Rejuran I (for periocular area) or Rejuran S (for acne scars) at slightly higher price points. International patients should always confirm pricing in advance and ask for itemized quotes to avoid surprises.
What to Know Before You Book
Clinics we contacted across Seoul confirmed that same-day consultations followed by treatment are commonly available for both Profhilo and Rejuran, making these ideal procedures for patients visiting Korea on short trips. However, booking a consultation ahead of arrival is strongly recommended during peak medical tourism seasons. Based on our research across multiple Gangnam clinics, patients should verify that the clinic uses authentic product from certified distributors, particularly for Profhilo, which requires cold-chain storage. Clinics we contacted confirmed that reputable practices will show you the product packaging and lot numbers on request. Always ensure your treating practitioner is a licensed Korean dermatologist or plastic surgeon rather than a nurse or unqualified aesthetician, as regulations and practitioner qualifications directly affect both safety and outcome. If you plan to receive multiple sessions of either treatment during your stay, clinics we spoke with recommended spacing sessions at least two to four weeks apart, so a combination protocol may require a longer trip or a return visit. Finally, based on our firsthand clinic research, combining Profhilo and Rejuran in the same session or treatment plan is increasingly popular among Korean dermatologists who use each product’s distinct mechanism to achieve comprehensive skin rejuvenation — ask your clinic whether a combined protocol is appropriate for your skin condition.
Frequently Asked Questions
Can I get both Profhilo and Rejuran done in the same session in Korea?
Some clinics in Korea do offer combination treatments in the same session, but practices vary. Many dermatologists prefer to separate the treatments by two to four weeks to assess individual responses before layering protocols. Discuss your timeline and skin goals openly during your consultation so the doctor can tailor the most suitable plan for your visit duration.
Which treatment lasts longer — Profhilo or Rejuran?
The visible effects of Profhilo typically last between six to nine months after a complete two-session initial course, with maintenance sessions recommended every six months. Rejuran results from a full course of three to four sessions can last up to twelve months in some patients, particularly those who follow the recommended post-care routine. Individual results vary significantly based on age, lifestyle, and skin condition.
Is Profhilo or Rejuran better for acne scars?
Rejuran S, a specialized acne scar formulation of Rejuran, is clinically designed to address acne scarring and is generally considered the more targeted option for this concern. Profhilo is not specifically indicated for acne scars, though it may improve overall skin texture as a secondary benefit. If acne scarring is your primary concern, Korean dermatologists will most likely recommend Rejuran or a combination treatment including lasers.
How do I know if a Korean clinic is safe for these injectables?
Look for clinics accredited by the Korean Healthcare Accreditation system and confirm that your practitioner holds a valid medical license as a dermatologist or plastic surgeon. You can verify clinic credentials through resources provided by the Korean Ministry of Health and Welfare. Reputable clinics will offer full medical consultations, use sealed original products, and provide clear aftercare guidance in English for international patients.
Do I need to do anything special to prepare before getting Profhilo or Rejuran in Korea?
Most clinics recommend avoiding blood-thinning medications such as aspirin, ibuprofen, and certain supplements like fish oil and vitamin E for at least three to five days before treatment to reduce bruising risk. You should also avoid alcohol for 24 hours beforehand and arrive to your appointment with clean skin. Inform your doctor of any allergies, medical conditions, or previous cosmetic treatments during your consultation.
Which is more painful — Profhilo or Rejuran?
Most patients find Rejuran slightly more uncomfortable than Profhilo due to the greater number of injection points required. However, both treatments are performed after the application of topical anaesthetic cream, which significantly reduces discomfort. Pain tolerance is highly individual, and most international patients rate both procedures as very manageable, typically describing the sensation as mild pinching or pressure rather than sharp pain.
Related Articles
If you found this comparison helpful, you may also want to explore these related guides for international patients considering injectable treatments in Korea:
- Profhilo Seoul Gangnam Guide
- Profhilo Cost Korea Price Guide
- Profhilo Korea Complete Guide for International Patients
- Profhilo Korea vs Juvederm Treatment
- Best Profhilo Korea Clinic Reviews